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    It MUST be something of value that could exist in no other time.

    It MUST be something of value that could exist in no other time.


     
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    IT IS LATER THAN YOU THINK!
(Previously.)

    IT IS LATER THAN YOU THINK!

    (Previously.)

     
  3. Analogy for a Resolving Agent

    Suppose you are blindfolded and asked to sort a pile of one hundred gloves into separate piles of right- and left-handed gloves.  (Never mind how you got into this predicament!) The gloves are identical except that fifty are right-handed, and fifty are left-handed.  The mixture of gloves is a “racemate.”  How would you separate them?  You can’t do it by weight, by smell, or by any other simple physical property, because right- and left-handed gloves have the same properties.   The way you do it, of course, is by trying each glove on your right (or left) hand.  Your hand thus acts as an “enantiomerically pure” chiral resolving agent.  A right-handed glove on your right hand generates a certain feeling (which we describe by saying “it fits”), and a left-handed glove on the right hand generates a totally different feeling.  You allow the hand (resolving agent) to interact with each glove, and you segregate the gloves on the basis of the resulting sensation.  You then break the hand-glove interaction (remove the glove) and put the glove in the appropriate pile.
    —Louden’s Organic Chemistry, 249.

    While it is not what I came here (i.e., TN) to do (e.g., make friends*) this is what I somehow ended up attempting to do daily.  (Chemical Enantiomeric Resolution, not glove sorting.  My cold-weather mittens are from the dollar store and there is no difference between L and R.  Though maybe a part of me really does spend a lot of time trying to get someone to hold my hand with reasonable “fit”.  Hmm.  Hm.) 

    It could be kind of a big deal if I get it to work, which is why I keep doing it.  The separations.  Maybe.  There is a lot of somewhat philosophical churn going on of late.

    *I stopped to try to remember what “reality” program remix included an “I didn’t come here to make friends!” montage, and I think it might be “all of them”.

     
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* DISCOVERY OF D-GLUCOSAMINE
In 1876 Georgg Ledderhose was a premedical student working in the laboratory of his uncle, Friedrich Wöhler (the same chemist who first synthesized urea).  One day, Wöhler had lobster for lunch, and returned to the laboratory carrying the lobster shell.  “Find out what this is,” he told his nephew.  History does not record Ledderhose’s thoughts on receiving the refuse from his uncle’s lunch, but he proceeded to do what all chemists did with unknown material.—he boiled it in concentrated HCl.  After hydrolysis of the shell, crystals of the previously unknown D-glucosamine hydrochloride precipitated from the cooled solution. 
(1367-Louden’s Organic Chemistry.)

Though  I am not the kind of chemist who does a lot of boiling in hydrochloric acid, roughly 50% of my graduate projects kind of started with leftovers. 
*That’s a meal that begins with an apology.

    * DISCOVERY OF D-GLUCOSAMINE

    In 1876 Georgg Ledderhose was a premedical student working in the laboratory of his uncle, Friedrich Wöhler (the same chemist who first synthesized urea).  One day, Wöhler had lobster for lunch, and returned to the laboratory carrying the lobster shell.  “Find out what this is,” he told his nephew.  History does not record Ledderhose’s thoughts on receiving the refuse from his uncle’s lunch, but he proceeded to do what all chemists did with unknown material.—he boiled it in concentrated HCl.  After hydrolysis of the shell, crystals of the previously unknown D-glucosamine hydrochloride precipitated from the cooled solution.

    (1367-Louden’s Organic Chemistry.)

    Though I am not the kind of chemist who does a lot of boiling in hydrochloric acid, roughly 50% of my graduate projects kind of started with leftovers. 

    *That’s a meal that begins with an apology.

     
  5. MUSICAL HISTORY OF THE ALDOL CONDENSATION

    Discovery of the aldol condensation is usually attributed solely to Charles Adolphe Wurtz, a French chemist who trained Friedel and Crafts.  However, the reaction was first investigated during the period 1864-1873 by Aleksandr Borodin, a Russian chemist who was also a self-taught and proficient composer of music.  (Borodin’s musical themes were used as the basis of songs in the musical Kismet.)  Borodin found it difficult to compete with Wurtz’s large, modern, well-funded laboratory.  Borodin also lamented that his professional duties so burdened him with “examinations and commissions” that he could only compose when he was home ill.  Knowing this, his musical friends used to greet him “Alexsandr, I hope you are ill today!”

    (1058-Louden’s Organic Chemistry.)


    Let me tell you about my sick-days: Some of my best projects.  It’s been a while.

     
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    Stupid evidence needs the most attention!
Collecting all sorts of evidence this weekend.  Mostly about conserved genetic traits.

Much like when I worried about getting lost in the desert with mummies, or eaten by the Rochester audience, or being shot in the head while re-enacting the Wire while singing Jungle-boy,  or stepped on by a Godzilla, everything will probably be fine.

As usual, however, in the case anything particularly stupid happens in Mexico: Love.

    Stupid evidence needs the most attention!

    Collecting all sorts of evidence this weekend.  Mostly about conserved genetic traits.

    Much like when I worried about getting lost in the desert with mummies, or eaten by the Rochester audience, or being shot in the head while re-enacting the Wire while singing Jungle-boy,  or stepped on by a Godzilla, everything will probably be fine.

    As usual, however, in the case anything particularly stupid happens in Mexico: Love.

     
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EMIL FISCHEREmil Fischer (1852-1919) studied with Adolph von Baeyer and ultimately became Professor at Berlin in 1892.  Fischer carried out important research on sugars, proteins (he devised the first rational synthesis of peptides), and heterocycles (for example, the  Fischer indole synthesis).  Fischer was a technical advisor to Kaiser Wilhelm.  The following story gives some indication of the authority that Fischer commanded in Germany.  It is said that one day he and the Kaiser were arguing questions of science policy, and the Kaiser sought to end debate by pounding his fist on the table, shouting “Ich bin der Kaiser!” (I am the King!) Fischer, not to be silenced, responded in kind: “Ich bin Fischer!”  Another story, perhaps apocryphal, attributes an important laboratory function to Fischer’s long flowing beard.  It was said that when a student had difficulty crystallizing a sugar derivative (some of which are notoriously difficult to crystallize), Fischer would shake his beard over the flask containing the recalcitrant compounds.  The accumulated seed crystals in his beard would fall into the flask and bring about the desired crystallization.  Fischer was awarded the Nobel Prize in 1902.¹  

“Seed Crystals”?  75% Dander.
(96+% of those tabs are anecdotal bits, I was not a good organic chemist.)
¹Loudon’s Organic Chemistry, p.1359

    EMIL FISCHER
    Emil Fischer (1852-1919) studied with Adolph von Baeyer and ultimately became Professor at Berlin in 1892.  Fischer carried out important research on sugars, proteins (he devised the first rational synthesis of peptides), and heterocycles (for example, the  Fischer indole synthesis).  Fischer was a technical advisor to Kaiser Wilhelm.  The following story gives some indication of the authority that Fischer commanded in Germany.  It is said that one day he and the Kaiser were arguing questions of science policy, and the Kaiser sought to end debate by pounding his fist on the table, shouting “Ich bin der Kaiser!” (I am the King!) Fischer, not to be silenced, responded in kind: “Ich bin Fischer!”  Another story, perhaps apocryphal, attributes an important laboratory function to Fischer’s long flowing beard.  It was said that when a student had difficulty crystallizing a sugar derivative (some of which are notoriously difficult to crystallize), Fischer would shake his beard over the flask containing the recalcitrant compounds.  The accumulated seed crystals in his beard would fall into the flask and bring about the desired crystallization.  Fischer was awarded the Nobel Prize in 1902.¹ 

    “Seed Crystals”?  75% Dander.

    (96+% of those tabs are anecdotal bits, I was not a good organic chemist.)

    ¹Loudon’s Organic Chemistry, p.1359